Mgr. Kristýna Tomášová / Department of the Molecular Biology of Cancer
Telomeric regions are the protective chromosome end caps formed by hexanucleotide tandem repeats and associated shelterin protein subunits, that play a critical role in maintaining genomic integrity. Genomic instability, driven by dysfunctional telomeres is a known mechanism in tumorigenesis. The system of telomere regulation is also vital in tumors to counter-balance the critical telomere shortening and thus ensure the limitless replicative potential of cancer cells and their virtual immortalization.