Invitation to the Institutional seminar of the IEM CAS - Identification of novel candidate biomarkers in early colorectal adenoma transition
Published 01. 06. 2022
We would like to invite you to the next Institutional seminar of the IEM CAS about "Identification of novel candidate biomarkers in early colorectal adenoma transition".
We look forward to your participation.
2nd June 2022 / 14:00 / Bordó seminar room of the IEM CAS
Ing. Anna Šišková / Department of the Molecular Biology of Cancer Annotation:
Colorectal adenoma, a protuberance from the epithelium of the intestine, is a precursor of colorectal cancer, the third most common cancer worldwide. Since the molecular mechanisms behind the early transformation into an adenoma are not well understood, we aimed to identify novel candidate genes by whole transcriptomic sequencing (WTS) of a larger cohort of adenomas and their corresponding adjacent tissue. The analysis revealed more than 2,000 differentially expressed genes (DEGs) between the adenoma and the adjacent tissue. Functional consequences of the gene signature were analyzed by proliferation assay, immunohistochemistry and in vivo in the chorioallantoic membrane (CAM) assay.