The Department of Neurochemistry studies molecular mechanisms that regulate the function of glutamate receptors in the mammalian central nervous system. We also aim to develop novel pharmacological compounds that act on glutamate receptors for the treatment of cognitive decline caused by neurodegeneration. Our experimental approach includes microscopy, biochemistry, and electrophysiology in cultured hippocampal neurones and human fibroblasts derived from patients with neurodegenerative diseases. Our long-term goal is to develop “personalised” compounds for treating specific neurodegenerative conditions including Alzheimer disease.
From the left: Marharyta Kolcheva, Kristýna Skřenková, Štěpán Kortus, Martin Horák, Martina Kaniaková, Barbora Krausová, Anna Misiachna.
Deputy Head:
Kristýna Skřenková, MSc
E-mail: kristyna.skrenkova@iem.cas.cz
Research Scientists:
Martin Horák, PhD.
Martina Kaniaková, PhD.
Barbora Krausová, PhD.
Oksana Forostyak, MD, PhD. (maternity leave)
Katarína Hemelíková, PhD. (maternity leave)
PhD. Students:
Marharyta Kolcheva, MSc
Štěpán Kortus, MSc
Anna Misiachna, MSc
Kristýna Skřenková, MSc
2019
Kaniakova M , Nepovinova E, Kleteckova L, Skrenkova K, Chrienova Z, Hepnarova V, Vales K, Soukup O, Korabecny J*, Horak M*. Combination of Memantine and 6-Chlorotacrine as Novel Multi-Target Compound against Alzheimer’s Disease. Current Alzheimer Research. IF=3.3
2018
Kaniakova M , Kleteckova L, Lichnerova K, Holubova K, Skrenkova K, Korinek M, Krusek J, Smejkalova T, Korabecny J, Vales K, Soukup O, Horak M*. 7-Methoxyderivative of tacrine is a 'foot-in-the-door' open-channel blocker of GluN1/GluN2 and GluN1/GluN3 NMDA receptors with neuroprotective activity in vivo. Neuropharmacology. 2018;140:217-232. IF=4.2
Skrenkova K , Lee S, Lichnerova K, Kaniakova M, Hansikova H, Zapotocky M, Suh YH*, Horak M*. N-Glycosylation Regulates the Trafficking and Surface Mobility of GluN3A-Containing NMDA Receptors. Front Mol Neurosci. 2018 Jun 4;11:188. IF=3.9
Regulation of the trafficking and function of GluN3A-containing NMDA receptors in mammalian neurones
GAČR, 18-04329S, 2018–2020
Role of transmembrane domain in transport and function of NMDA receptors
GAUK, 468217, 2017–2019
National Institute of Mental Health, Klecany
Biomedical Research Center, Hradec Kralove
Neuroscience Research Institute, Seoul National University College of Medicine, Republic of Korea
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