The Department of Neurochemistry studies molecular mechanisms that regulate the function of glutamate receptors in the mammalian central nervous system. We also aim to develop novel pharmacological compounds that act on glutamate receptors for the treatment of cognitive decline caused by neurodegeneration. Our experimental approach includes microscopy, biochemistry, and electrophysiology in cultured hippocampal neurones and human fibroblasts derived from patients with neurodegenerative diseases. Our long-term goal is to develop “personalised” compounds for treating specific neurodegenerative conditions including Alzheimer disease.
From the left: Kristýna Skřenková, Jakub Netolický, Anna Misiachna, Martin Horák, Paula Rivas Ramirez, Marharyta Kolcheva, Petra Baráčková, Štěpán Kortus
Deputy Head:
Mgr. Kristýna Skřenková, Ph.D.
E-mail: kristyna.skrenkova@iem.cas.cz
Research Scientists:
Mgr. Martin Horák, Ph.D.
Ing. Štěpán Kortus, Ph.D.
Paula Rivas Ramirez, Ph.D.
Mgr. Kristýna Skřenková, Ph.D.
PhD. Students:
Mgr. Marharyta Kolcheva
Emily Langore, M.Sc.
Mgr. Anna Misiachna
Mgr. Jakub Netolický
Lab Manager:
Mgr. Petra Baráčková
2019
Skrenkova K , Hemelikova K, Kolcheva M, Kortus S, Kaniakova M, Krausova B, Horak M. Structural features in the glycine-binding sites of the GluN1 and GluN3A subunits regulate the surface delivery of NMDA receptors. Scientific reports 9:12303.
Hemelikova K , Kolcheva M, Skrenkova K, Kanikova M, Horak M. Lectins modulate the functional properties of GluN1/GluN3A – containg receptors. Neuropharmacology 157, 107671.
Kaniakova M , Nepovinova E, Kleteckova L, Skrenkova K, Chrienova Z, Hepnarova V, Vales K, Soukup O, Korabecny J*, Horak M*. Combination of Memantine and 6-Chlorotacrine as Novel Multi-Target Compound against Alzheimer’s Disease. Current Alzheimer Research 2019;16(9):821-833.
2018
Kaniakova M , Kleteckova L, Lichnerova K, Holubova K, Skrenkova K, Korinek M, Krusek J, Smejkalova T, Korabecny J, Vales K, Soukup O, Horak M*. 7-Methoxyderivative of tacrine is a 'foot-in-the-door' open-channel blocker of GluN1/GluN2 and GluN1/GluN3 NMDA receptors with neuroprotective activity in vivo. Neuropharmacology. 2018;140:217-232.
Skrenkova K , Lee S, Lichnerova K, Kaniakova M, Hansikova H, Zapotocky M, Suh YH*, Horak M*. N-Glycosylation Regulates the Trafficking and Surface Mobility of GluN3A-Containing NMDA Receptors. Front Mol Neurosci. 2018 Jun 4;11:188.
Dually acting cognitive enhancers for palliative treatment of Alzheimer´s disease
AZV,
NU20-08-00296, 2020-2024
Delineating the mechanisms that regulate specific NMDA receptor subtypes in mammalian neurones
GAČR, 20-12420S, 2020-2023
Novel neuroprotective compounds based on NMDA receptor antagonism and cholinergic stimulation
GAČR, 20-12047S, 2020-2023
The Institute of Organic Chemistry and Biochemistry CAS, Prague, Czech Republic
Mgr. et Mgr. Evžen Bouřa, Ph.D.
Institute of Physiology CAS, Prague, Czech Republic
RNDr. Martin Zápotocký, Ph.D.
National Institute of Mental Health, Klecany, Czech Republic
RNDr. Karel Valeš, Ph.D.
Biomedical Research Center, Hradec Králové, Czech Republic
Doc. Ondřej Soukup, Ph.D.
Neuroscience Research Institute, Seoul National University College of Medicine, Soul, Republic of Korea
Assoc. Prof. Young Ho Suh, Ph.D.
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