Institute of Experimental Medicine CAS

A deficiency of the link protein Bral2 affects the size of the extracellular space in the thalamus of aged mice.

Deficiency in a link protein Bral2, which stabilizes the extracellular matrix complexes, leads to a reduction of perineuronal nets and axonal coats in the thalamic ventral posteromedial nucleus (VPM) of both young and aged mice However, a decrease in the extracellular volume was observed only in aged animals. Our data suggest that the effect of Bral2 deficiency on the VPM diffusion is probably indirect and mediated through the enhanced age-related damage of neurons lacking protective shields.

Collaboration: Department of Neuroscience, Second Faculty of Medicine Charles University

Contact person: doc. MUDr. Lýdie Vargová, PhD; tel: 241 062 643; vargova@biomed.cas.cz

Publication:
Cicanic, M; Edamatsu, M; Bekku, Y; Vorisek, I; Oohashi, T; Vargova, L . A deficiency of the link protein Bral2 affects the size of the extracellular space in the thalamus of aged mice. J Neurosci Res. 2018 Feb;96(2):313-327. doi: 10.1002/jnr.24136. 

 

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Deficiency for a link protein Bral2, associated with a disruption of brevican-based axonal coats (arrow), significantly affect tissue diffusivity in the thalamic ventroposteromedial nucleus in the aged but not in the young mice.