Institute of Experimental Medicine CAS

Adaptation of the human population to the environment: Current knowledge, clues from Czech cytogenetic and "omics" biomonitoring studies and possible mechanisms.

A comprehensive overview of the last decade of Czech biomonitoring research, concerning the effect of various levels of air pollution and radiation, on the differently exposed population groups. A detailed analysis of data leads to a hypothesis of the versatile mechanism of adaptation to environmental stressors via DNA methylation settings which may even originate in prenatal development, and help to reduce the resulting DNA damage levels.

Collaboration: University of South Bohemia in Ceske Budejovice

Contact person: Mgr. Andrea Rossnerova, Ph.D.; tel.: 241 062 053; andrearo@biomed.cas.cz

Publication:
Rössnerová, A.,Pokorná, M.,Švecová, V.,Šrám, R.,Topinka, J., Zölzer, F., Rössner, P.: (2017) Adaptation of the human population to the environment: Current knowledge, clues from Czech cytogenetic and "omics" biomonitoring studies and possible mechanisms. Mutation Research-Reviews in Mutation Research. 773: 188-203. IF=5.5. doi: 10.1016/j.mrrev.2017.07.002. Epub 2017 Jul 12. Review.

 

adaptace

 

A model of epigenetic mechanism providing the link between changes of environmental factors during life and the levels of DNA damage.