Institute of Experimental Medicine CAS

vav-cejkova-2018-1

Molecular hydrogen effectively heals the alkali-burned cornea via suppression of oxidative stress, decreases the inflammation in the anterior eye segment and prevents corneal neovascularization.

The alkali-burn of the anterior eye segment evokes oxidative stress. The antioxidant mechanisms are exhausted leading to the antioxidant/prooxidant imbalance which is immediately followed by the protease/antiprotease imbalance. This situation results in the excessive inflammation. When the molecular hydrogen is dropped on the anterior eye surface early after the injury, it suppresses oxidative stress and thus decreases the inflammation and promotes the healing process.

Contact person: doc. MUDr. Jitka Čejková, DrSc.; tel.: 241 062 208; cejkova@biomed.cas.cz

Publication:
Čejka, Č., Kössl, J., Heřmánková, B., Holáň, V., Čejková, J.: (2017) Molecular Hydrogen Effectively Heals Alkali-Injured Cornea via Suppression of Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2017;2017:8906027. doi: 10.1155/2017/8906027. Epub 2017 Mar 16.

vav-cejkova-2018-2

The healing of the rabbit eye after alkali burn after the treatment with buffer or buffer with H2. The cornea healed with H2 is transparent with no sign of neovascularization (day 20). The treatment with H2 significantly decreased expression of vascular endothelial growth factor, which is characteristic for neovascularization.