Ischemic or traumatic injury in central nervous system (CNS) increases NG2 cell proliferation and expands their differentiation potential, which might ultimately contribute to regeneration of damaged nervous tissue.
We summarize the current knowledge about NG2 cell proliferation, their fate plasticity during embryogenesis and in postnatal CNS under physiological and pathological conditions, with the emphasis on the role of signaling molecules, growth factors, hormones or even neurotransmitters on the fate potential of NG2 cells. They are well-known for their ability to generate new oligodendrocytes, however following CNS injuries, such as demyelination, trauma or ischemia, the proliferative capacity of NG2 cells rapidly increases and their differentiation potential broadens.
Ing. Miroslava Anděrová, CSc.; tel: 241 062 050; email@example.com
Valny, M; Honsa, P; Kriska, J; Anderova, M. Multipotency and therapeutic potential of NG2 cells, Biochemical Pharmacology, 2017, Volume: 141 Pages: 42-55 Special Issue DOI: 10.1016/j.bcp.2017.05.008
Proliferation and differentiation of NG2 cells under physiological conditions and following CNS injuries. During embryogenesis of CNS and postnatally NG2 cells give rise to astrocytes and oligodendrocytes, while following injury they give rise to oligodendrocytes, reactive astrocytes and rarely, to immature neurones.