Institute of Experimental Medicine CAS

Publikováno 02. 01. 2023

Let's look back at the past year in terms of the publishing activities of our Institute. In 2022, our research published 90 scientific papers with a total IF 595.52 (average IF 6.62). Among the most productive departments of the IEM CAS are:

• Department of the Molecular Biology of Cancer (21 publications),
• Department of Neuroregeneration (15 publications),
• Centre for Reconstructive Neuroscience  (10 publications),
• Department of Nanotoxicology and Molecular Epidemiology (10 publications),
• Department of Genetic Toxicology and Epigenetics  (10 publications).

Here is an overview of the best publications of the IEM CAS:

Publication with a high contribution of the authors from the IEM CAS: ​​​

• Fawcett, J.W., Fyhn, M., Jendelová, P., Kwok, J.C.F., Růžička, J., Sorg, B.: (2022) The extracellular matrix and perineuronal nets in memory. Molecular Psychiatry. IN PRESS
• Arzhanov, I., Sintakova, K.,  Romanyuk, N.: (2022) The Role of miR-20 in Health and Disease of the Central Nervous System. Cells. 11(9): 1525.
• Růžička, J.,  Dalecká, M.,  Šafránková, K.,  Peretti, D.,  Jendelová, P., Kwok, J.C.F.,  Fawcet, J.W.: (2022) Perineuronal nets affect memory and learning after synapse withdrawal. Translational Psychiatry. 12(1):480.
• Fábik, J., Psutková, V.,  Machoň, O.: (2022) Meis2 controls skeletal formation in the hyoid region. Frontiers in Cell and Developmental Biology. 28(10): 951063.
• Vargová, I., Kriška, J., Kwok, J.C.F., Fawcett, J.W., Jendelová, P: (2022) Long-Term Cultures of Spinal Cord Interneurons. Frontiers in Cellular Neuroscience. 16: 827628
• Zahumenský, J. , Fernandes, C.M.,  Veselá, P.,  Del Poeta, M., Konopka, J.B.,  Malínský, J.: (2022) Microdomain Protein Nce102 Is a Local Sensor of Plasma Membrane Sphingolipid Balance. Microbiology Spectrum. 10(4): e0196122.
• Žižková, R., Hedvičáková, V., Blahnová Hefka, V., Sovková, V., Rampichová, M., Filová, E.: (2022) The Effect of Osteoblast Isolation Methods from Adult Rats on Osteoclastogenesis in Co-Cultures. International Journal of Molecular Sciences. 23(14):7875.
• Haveliková, K., Smejkalová, B.,  Jendelová, P.: (2022) Neurogenesis as a Tool for Spinal Cord Injury. International Journal of Molecular Sciences. 23(7): 3728.
• Holáň, V., Echalar, B., Palacká, K., Kössl, J., Bohačová, P., Porubská, B., Krulová, M., Javorková, E., Zajicová, A.: (2022) The Inability of Ex Vivo Expanded Mesenchymal Stem/Stromal Cells to Survive in Newborn Mice and to Induce Transplantation Tolerance. Stem Cell Reviews and Reports. 18(7): 2365-2375.
• Suchá, P.,  Heřmanová, Z., Chmelová, M., Kirdajová, D., Camacho Garcia, S., Marchetti, V., Voříšek, I., Turečková, J., Shany, E., Jirák, D., Anděrová, M., Vargová, L.: (2022) The absence of an AQP4/TRPV4 complex substantially reduces acute cytotoxic edema following ischemic injury. Frontiers in Cellular Neuroscience. IN PRESS
• Hoňková, K., Rössnerová, A., Chvojková, I., Milcová, A., Margaryan, H., Pastorková, A., Ambrož, A., Rössner, P., Jirik, V., Rubeš, J., Šrám, R.J., Topinka, J.: (2022) Genome-Wide DNA Methylation in Policemen Working in Cities Differing by Major Sources of Air Pollution. International Journal of Molecular Sciences. 23(3):1666.
• Paul, J.Ch.,  Fulka, H.: (2022) Nuclear Lamins: Key Proteins for Embryonic Development. Biology-Basel. 11(2): 198.

Publication with the highest normalized IF:  

• Tansley, S., Gu, N., Guzman, A. U., Cai, W., Wong, C., Lister, K.C., Munoz-Pino, E., Yousefpour, N., Roome, R. B., Heal, J., Wu, N., Castonguay, A., Lean, G., Muir, E. M., Kania, A., Prager-Khoutorsky, M., Zhang, J., Gkogkas, Ch.G., Fawcett, J.W., Diatchenko, L., Ribeiro-da-Silva, A., De Koninck, Y., Mogil, J., Khoutorsky, A.: (2022) Microglia-mediated degradation of perineuronal nets promotes pain. Science. 377(6601): 80-86.
• Fernandez-Rozadilla, C., Timofeeva, M., Chen, Z., Law, P., Thomas, M., Schmit, S., Díez-Obrero, V., Hsu, L., Fernandez-Tajes, J., Palles, C., Sherwood, K., Briggs, S., Svinti, V., Donnelly, K., Farrington, S., Blackmur, J., Vaughan-Shaw, P., Shu, X., Long, J., Cai, Q., Guo, X., Lu, Y., Broderick, P., Huyghe, H., Harrison, T., Conti, D., Dampier, D., Schumacher, F., Melas, M., Rennert, G., Santacana, M.O., Martín-Sánchez, V., Moratalla-Navarro, F., Hwan, J., Kim, J., Jee, S.H., Jung, K.J., Kweon, S.S., Shin, M.H., Shin, A.,  Ahn, Y.O., Kim, D.H., Oze, I., Wen, W., Matsuo, K., Matsuda, K., Tanikawa, Ch., Ren, Z., Gao, Y.T., Jia, W.H., Hopper, J., Jenkins, M., Win, A.K., Pai, R., Figueiredo, J., Haile4, R., Gallinger, S., Woods, M., Newcomb, P., Duggan, D., Cheadle, J., Kaplan, R., Maughan, T., Kerr, R., Kerr, D., Kirac,I., CORGI study investigators59 16 , SCOT  trial translational group and investigators, Böhm, J., Mecklin, J.P., Jousilahti, P., Knekt, P., Aaltonen, L., Rissanen, H., Pukkala, E., Eriksson, J., Cajuso, T., Hänninen, U., Kondelin, J., Palin, K., Tanskanen, T., Renkonen-Sinisalo, L., Zanke, B., Männistö, S., Albanes, D., Weinstein, S., Ruiz-Narvaez, E., Palmer, J., Buchanan, D., Platz, E., Visvanathan, K., Ulrich, C., Siegel, E., Brezina, S., Gsur, A., Campbell, P., Chang-Claude, J., Hoffmeister, M., Brenner, H.,  Slattery, M., Potter, J., Tsilidis, T., Schulze, M., Gunter, M., Murphy, N., Castells, A., Castellví-Bel, S., Moreira, L., Arndt, V., Shcherbina, A., Stern, M., Pardamean, B., Bishop, T., Giles, G., Southey, M., Idos, G., McDonnell, K., Abu-Ful, Z., Greenson, J., Shulman, K., Lejbkowicz, F., Offit, K., Su, Y.R., Steinfelder, R., Keku, T., van Guelpen, B., Hudson, T., Hampel, H., Pearlman, R., Berndt, S., Hayes, R., Martinez, M.E., Thomas, S., Corley, D., Pharoah, P., Larsson, S., Yen. Y., Lenz, H.J., White, E., Li, L., Doheny, K., Pugh, E., Shelford, T., Chan, A., Cruz-Correa, M., Lindblom, A., Hunter, D., Joshi, A., Schafmayer, C., Scacheri, P., Kundaje, A., Nickerson, D., Schoen, R., Hampe, J., Stadler, Z., Vodička, P., Vodičková, L., Vymetálková, L.,  Papadopoulos, N., Edlund, Ch., Gauderman, W., Thomas, D., Shibata, D., Toland, D., Markowitz, S., Kim, A., Chanock, S., van Duijnhoven, F., Feskens, E., Sakoda, L., Gago-Dominguez, M., Wolk, A., Naccarati, A., Pardini, B., FitzGerald, L., Chin, S., Lee, S.Ch., Ogino, S., Bien, S.,  Kooperberg, Ch., Li, Ch., Lin, Y., Prentice, R., Qu, C., Bézieau, S., Tangen, C., Mardis, E., Marchand, L.L., Wu, A., Qu, Ch., McNeil, C., Coetzee, G., Hayward, C., Deary, I., Harris, S., Theodoratou, E., Reid, S., Walker, M., Ooi, L.Y., Moreno, V., Casey, G., Gruber, S., Tomlinson, I., Zheng, W., Dunlop, M., Houlston, R., Peters, P.: (2022) Multi-omic analysis of 100,204 Europeans and Asians identifies 103 new  2 colorectal cancer risk associations and provides insights into disease etiology. Nature Genetics. IN PRESS
• Grotz, S., Schaefer, J.,Wunderlich, K.A., Ellederova, Z., Auch, H., Baehr, A., Runa-Vochozkova, P., Fadl, J., Arnold, V., Ardan, T., Veith, M., Santamaria, G., Dhom, G., Hitzl, W., Kessler, B., Eckardt, Ch., Klein, J., Brymova, A., Linnert, J., Kurome, M., Zakharchenko, V., Fischer, A., Blutke, A., Doering, A., Suchánková, Š., Popelář, J., Rodriguez-Bocanegra, E., Dlugaiczyk, J., Straka, H., May-Simera, H., Wang, W., Laugwitz, K.L., Vandenberghe, L.H., Wolf, E., Nagel-Wolfrum, K., Peters, T., Motlik, J., Fischer, M.D., Wolfrum, U., Klymiuk, N.: (2022) Early disruption of photoreceptor cell architecture and loss of vision in a humanized pig model of usher syndromes. EMBO Molecular Medicine. 14(4):e14817.
• Fawcett, J.W., Fyhn, M., Jendelová, P., Kwok, J.C.F., Růžička, J., Sorg, B.: (2022) The extracellular matrix and perineuronal nets in memory. Molecular Psychiatry. IN PRESS
• Filová, I., Pysanenko, K., Tavakoli, M., Vochyanova, S., Dvořáková, M., Bohuslavová, R., Smolík, O., Fabriciová, V., Hrabalová, P., Benešová, Š., Valihrach, L.,  Černý, J., Yamoah, E.N., Syka, J., Fritzsch, B., Pavlinková, G.: (2022) ISL1 is necessary for auditory neuron development and contributes toward tonotopic organization. Proceedings of the National Academy of Sciences of the United States of America. 119(37): e2207433119.
• Barone, D.G., Carnicer-Lombarte, A., Tourlomousis, P., Hamilton, R.S., Prater, M., Rutz, A.L., Dimov, I.B., Malliaras, G.G., Lacour, S.P., Robertson, A.A.B., Franze, K., Fawcett, W.J., Bryant, C.E.: (2022) Prevention of the foreign body response to implantable medical devices by inflammasome inhibition. Proceedings of the National Academy of Sciences of the United States of America. 119(12): e2115857119
• Murphy, N.,  Song, M., Papadimitriou, N., Carreras-Torres, R., Langenberg, C., Martin, R.M., Tsilidis, K.K., Barroso, I., Chen, J., Frayling, T., Bull, C.J., Vincent, E.E., Cotterchio, M., Gruber, S.B., Pai, R.K., Newcomb, P.A., Perez-Cornago, A., van Duijnhoven, F.J.B., Van Guelpen, B., Vodička, P., Wolk, A., Wu, A.H., Peters, U., Chan, A.T., Gunter, M.: (2022) Associations Between Glycemic Traits and Colorectal Cancer: A Mendelian Randomization Analysis. JNCI-Journal of the National Cancer Institute. 114(5): 740-752.
• Clay-Gilmour, A., Chattopadhyay, S., Hildebrandt, M.A.T., Thomsen, H., Weinhold, N., Vodička, P., Vodičková, L., Hoffmann, P., Nothen, M.M., Jockel, K.H., Schmidt, B., Langer, Ch.,Hájek, R., Hallmans, G., Pettersson-Kymmer, U., Ohlsson, C., Spath, F., Houlston, R., Goldschmidt, H., Manasanch, E.E., Norman, A., Kumar, S., Rajkumar, S.V., Slager, S., Forsti, A., Vachon, C.M., Hemminki, K.: (2022) Genome-wide meta-analysis of monoclonal gammopathy of undetermined signifikance (MGUS) identifies risk loci impacting IRF-6. Blood Cancer Journal. 12(4):60
• Tsilidis, K.K.,  Papadimitriou, N., Dimou, N., Gill, D., Lewis, S.J., Martin, R.M., Murphy, N., Markozannes, G., Zuber, V., Cross, A.J., Burrows, K., Lopez, D.S., Key, T.J., Travis, R.C., Perez-Cornago, A., Hunter, D.J., van Duijnhoven, F.J.B., Albanes, D., Arndt, V., Berndt, S.I., Bezieau, S., Bishop, D. T., Boehm, J., Brenner, H., Burnett-Hartman, A., Campbell, P.T., Casey, G., Castellvi-Bel, S., Chan, A.T., Chang-Claude, J., de la Chapelle, A., Figueiredo, J.C., Gallinger, S.J., Giles, G.G., Goodman, P.J., Gsur, A., Hampe, J., Hampel, H., Hoffmeister, M., Jenkins, M., Keku, T.O., Kweon, S.S., Larsson, S.C., Le Marchand, L., Li, Ch.I., Li, L., Lindblom, A., Martin, V., Milne, R.L., Moreno, V., Nan, H., Nassir, R., Newcomb, P.A., Offit, K., Pharoah, P.D.P., Platz, E.A., Potter, J.D., Qi, L., Rennert, G., Sakoda, L.C., Schafmayer, C., Slattery, M.L., Snetselaar, L., Schenk, J., Thibodeau, S.N., Ulrich, C.M., Van Guelpen, B., Harlid, S., Visvanathan, K., Vodičková, L., Wang, H., White, E., Wolk, A., Woods, M.O., Wu, A.H., Zheng, W., Bueno-de-Mesquita, B., Boutron-Ruault, M.Ch., Hughes, D.J., Jakszyn, P., Kuehn, T., Palli, D., Riboli, E., Giovannucci, E.L., Banbury, B.L., Gruber, S.B., Peters, U., Gunter, M.J.: (2021) Genetically predicted circulating concentrations of micronutrients and risk of colorectal cancer among individuals of European descent: a Mendelian randomization study. American Journal of Clinical Nutrition. 113(6): 1490-1502.
• Zahumenský, J. , Fernandes, C.M., Veselá, P., Del Poeta, M., Konopka, J.B., Malínský, J.: (2022) Microdomain Protein Nce102 Is a Local Sensor of Plasma Membrane Sphingolipid Balance. Microbiology Spectrum. 10(4): e0196122.
• Balažová, M.,  Veselá, P., Babelová, L., Durisová, I., Kanovicová, P., Záhumenský, J., Malínský, J.: (2022) Two different phospholipases C, Isc1 and Pgc1, cooperate to regulate mitochondrial function. Microbiology Spectrum. IN PRESS.
• Zhang, X., Lu, Ch., Li, Y., Norbäck, D., Murthy, P., Šrám, R.J., Deng, Q.: (2023) Early-life exposure to air pollution associated with food allergy in children: Implications for 'one allergy' concept. Environmental Research. 216: 114713