Institute of Experimental Medicine of the CAS

Biomedical research towards effective diagnosis and treatment

About Us

Research

Study & Careers


News

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Can interspecies embryos help save endangered species? A new review summarises the current evidence

PublicationResearch Published on 29. 07. 2026 Reading time: 3 minutes

Kristýna Kárová: Making a discovery is only the beginning. What comes next matters just as much.

ArticleInterview Published on 23. 07. 2026 Reading time: 1 minute

An international study published in Nature Communications offers a new perspective on the mechanisms of replication stress and genomic instability.

PublicationResearch Published on 21. 07. 2026 Reading time: 5 minutes

Tereza Červená won first place in the best poster competition at an international toxicology conference

Award Published on 16. 07. 2026 Reading time: 2 minutes

The laboratory instead of the classroom: The students at the Jiří Orten Gymnasium were exploring cells and biomaterials at a glance

Popularisation of Science Published on 08. 07. 2026 Reading time: 2 minutes

Doctoral student Magui Khazaal won the Central European final of the “Ma thèse en 180 secondes” competition

Award Published on 07. 07. 2026 Reading time: 1 minute
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Events

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03. 09. 2026

Institutional Seminar Series 9/2026

Professional EventsSeminar

08. 09. 2026 - 09. 09. 2026

From Animal Handling to Data: Imaging Facilities in Preclinical Research

CourseCzech-BioimagingMicroscopy

01. 10. 2026

Institutional Seminar Series 10/2026

Professional EventsSeminar

05. 11. 2026

Institutional Seminar Series 11/2026

Professional EventsSeminar

02. 12. 2026 - 04. 12. 2026

Introduction to programming for image processing

CourseCzech-BioimagingMicroscopy
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About Us

We are a renowned centre of basic biomedical research in the Czech Republic and worldwide. Our projects are focused on biomedical challenges, such as finding effective diagnostic markers and treatment of serious diseases associated with ageing of the human population (neurodegeneration, trauma, ischemia, musculoskeletal disorders, cancer and degenerative changes in vision and hearing). We also seriously consider the impact of environmental pollution on human health.

  • We are a proud holder of the “HR Excellence in Research” and “Ethnic Friendly Employer” awards.
  • We are a member of the Euro-BioImaging, Czech-BioImaging, EATRIS, and NanoEnviCz infrastructures.
More information
Annual Brochure 2023 – 2024 (pdf, 28616 kB)
  • 1975 Established
  • 220 Employees
  • 31 Projects
  • 79 Publications (2025)

Research Departments and Centres

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Department of Cellular Neurophysiology

Research Department

Head of the Department

Jana Turečková

Department of Auditory Neuroscience

Research department

Head of the Department

Rostislav Tureček

Department of Toxicology and Molecular Epidemiology

Research Department

Head of the Department

Pavel Rössner

Department of Molecular Biology of Cancer

Research Department

Head of the Department

Veronika Vymetálková

Department of Cell Nucleus Plasticity

Research Department

Head of the Department

Helena Fulková

Department of Neuroregeneration

Research Department

Head of the Department

Pavla Jendelová

Centre for Reconstructive Neuroscience

Research Centre

Head of the Research Centre

James Fawcett

Department of Neurochemistry

Research Department

Head of the Department

Martin Horák

Department of Genome Biology

Research department

Head of Department

Martin Andrš

Department of Developmental Biology

Research Department

Head of the Department

Ondřej Machoň

Department of Tissue Engineering

Research Department

Head of the Department

Eva Filová

Department of Functional Organisation of Biomembranes

Research Department

Head of the Department

Jan Malínský

Department of Neurogenetics

Research Department

Head of the Department

Lenka Šlachtová

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Latest Publications

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Transcriptional responses to real-world ambient air pollution in healthy and asthmatic human 3D airway models grown at the air-liquid interface

 Department of Toxicology and Molecular Epidemiology AutořiŠímová Z.Líbalová H.Šíma M.Vrbová K.Červená T.Vimrová A.Dittrich L.Vojtíšek M.Pechout M.Klema J.Rössnerová A.Rössner P. Published on 2026 Metadata Journal of Hazardous Materials Advances Volume 23, August 2026, 101404, https://doi.org/10.1016/j.hazadv.2026.101404

Should posthumously retrieved mammalian spermatozoa be evaluated via interspecific ICSI?

 Department of Cell Nucleus Plasticity AutořiVackova K.Rychtarova J.Fulka H.Fulka Jr. J. Published on 2026 Metadata J Assist Reprod Genet . 2026 Jul 10. doi: 10.1007/s10815-026-03970-7. Online ahead of print.

PARG inhibition reduces ssDNA levels and limits RPA loading upon replication fork collapse

 Department of Genome Biology AutořiMihuț A.Ghosh D.Kószó A.Szüts D.Andrs Salajkova S.Andrš M.Dobrovolná J.Fajka-Boja R.Timinszky G. Published on 2026 Metadata EMBO Rep . 2026 Jul 4. doi: 10.1038/s44319-026-00848-8. Online ahead of print.

CEMIP1 and TACSTD2 as circulating mRNA biomarkers for early detection and tumor burden assessment in colorectal neoplasia

 Department of Molecular Biology of Cancer AutořiBalounová K.Uttarilli A.Horák J.Makajevova V.Sojka L.Simsa J.Bruha J.Liska V.Selvi S.Korenkova V.Vodenková S.Jungwirth J.Macinga P.Hucl T.Kral J.Schneiderova M.Valíčková (Šišková) A.Vymetálková V. Published on 2026 Metadata Mol Med . 2026 Jun 25. doi: 10.1186/s10020-026-01537-x. Online ahead of print.

Elongation of spinal cord reactive astrocytes via LRP1/TRK signaling

 Department of Neuroregeneration AutořiRodriguez-Jimenez F. R.Selles F.Jendelová P.Erceg S. Published on 2026 Metadata Signal Transduct Target Ther . 2026 Jun 1;11(1):206. doi: 10.1038/s41392-026-02660-1.

Molecular alterations in human olfactory mucosal cells from healthy individuals and individuals with Alzheimer's disease induced by real-world ambient air

 Department of Toxicology and Molecular Epidemiology AutořiRössner P.Líbalová H.Šíma M.Červená T.Šímová Z.Vrbová K.Ambrož A.Rössnerová A.Nováková Z.Elzeinová F.Vimrová A.Klema J.Koivisto A.M.Penttilä E.Dittrich L.Vojtisek M.Pechout M.Kanninen K.M.Vojtisek-Lom M. Published on 2026 Metadata Environ Toxicol Pharmacol . 2026 Jun:124:105019. doi: 10.1016/j.etap.2026.105019. Epub 2026 Apr 12.

DNA damage in the leukocytes of nanocomposite-exposed workers

 Department of Toxicology and Molecular Epidemiology AutořiRössner P.Novotná B.Pelclova D.Zdimal V.Lischkova L.Klusackova P.Ondracek J.Schwarz J.Maskova L.Dvorackova S.Milcová A.Ambrož A.Rössnerová A. Published on 2026 Metadata Mutagenesis . 2026 May 22:geag021. doi: 10.1093/mutage/geag021. Online ahead of print.

Distinct mechanisms of replication stress induced by oncogenic RAS and cyclin E1 converge on R-loop-dependent fork reversal

 Department of Genome Biology AutořiOravetzova A.Dvorakova M.Mihai A.-I.Andrš M.Sobol M.Zuev A.Shukla K.Boleslavska B.Rosano V.König Ch.Prokes J.Hanzlikova H.Macurek L.Dobrovolná J.Janscak P. Published on 2026 Metadata Nat Commun. 2026 Apr 3;17(1):4784. doi: 10.1038/s41467-026-71353-8.

The role of disulfide bonds in the GluN1 subunit in the early trafficking and functional properties of GluN1/GluN2 and GluN1/GluN3 NMDA receptors

 Department of Neurochemistry AutořiNetolický J.Lee S.Baráčková P.Kolcheva M.Misiachna A.Řeháková K.Kortus S.Song J-MHemelíková K.Langore E.Doderović J.Ladislav M.Ho Suh Y.Horák M. Published on 2026 Metadata J Neurosci . 2026 Feb 24:e0409252026. doi: 10.1523/JNEUROSCI.0409-25.2026. Online ahead of print.
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