Institute of Experimental Medicine of the CAS

Biomedical research towards effective diagnosis and treatment

About Us

Research

Study & Careers


News

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A refined look at the hidden links of glutamate receptors: Disulfide bonds shape the trafficking and function of NMDA receptors

PublicationResearch Published on 17. 04. 2026 Reading time: 3 minutes

Exceptional interest in PhD positions ot the IEM CAS

CareerPhD Study Published on 17. 04. 2026 Reading time: 1 minute

IEM CAS is seeking a Head of the Research Department

CareerOpen Position Published on 07. 04. 2026 Reading time: 1 minute

New study in the Molecular Medicine journal: What can mitochondria reveal about the development of colorectal cancer?

PublicationResearch Published on 11. 03. 2026 Reading time: 5 minutes

Kristýna Kárová has excelled in the Lorem Ipsum Executive Academy

Award Published on 06. 03. 2026 Reading time: 2 minutes

Axon Repair 2026: The future of nerve tissue regeneration research discussed at Villa Lanna

Professional EventsSymposium Published on 05. 03. 2026 Reading time: 3 minutes
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Events

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28. 04. 2026

μLectures: Choosing a microscopy technique

Czech-BioimagingMicroscopyμLectures

07. 05. 2026

Institutional Seminar Series 5/2026

Professional EventsSeminar

28. 05. 2026 - 29. 05. 2026

Advanced 3D image visualization and quantification

CourseCzech-BioimagingMicroscopy

04. 06. 2026

Institutional Seminar Series 6/2026

Professional EventsSeminar

07. 06. 2026 - 11. 06. 2026

Xenobiochemistry Symposium: Genetic Toxicology and Cancer Prevention 2026

ConferenceProfessional Events

02. 12. 2026 - 04. 12. 2026

Introduction to programming for image processing

CourseCzech-BioimagingMicroscopy
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About Us

We are a renowned centre of basic biomedical research in the Czech Republic and worldwide. Our projects are focused on biomedical challenges, such as finding effective diagnostic markers and treatment of serious diseases associated with ageing of the human population (neurodegeneration, trauma, ischemia, musculoskeletal disorders, cancer and degenerative changes in vision and hearing). We also seriously consider the impact of environmental pollution on human health.

  • We are a proud holder of the “HR Excellence in Research” and “Ethnic Friendly Employer” awards.
  • We are a member of the Euro-BioImaging, Czech-BioImaging, EATRIS, and NanoEnviCz infrastructures.
More information
Annual Brochure 2023 – 2024 (pdf, 28616 kB)
  • 1975 Established
  • 220 Employees
  • 31 Projects
  • 79 Publications (2025)

Research Departments and Centres

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Department of Auditory Neuroscience

Research department

Head of the Department

Rostislav Tureček

Department of Cellular Neurophysiology

Research Department

Head of the Department

Miroslava Anděrová

Department of Genome Biology

Research department

Head of Department

Martin Andrš

Centre for Reconstructive Neuroscience

Research Centre

Head of the Research Centre

James Fawcett

Department of Developmental Biology

Research Department

Head of the Department

Ondřej Machoň

Department of Neurochemistry

Research Department

Head of the Department

Martin Horák

Department of Toxicology and Molecular Epidemiology

Research Department

Head of the Department

Pavel Rössner

Department of Tissue Engineering

Research Department

Head of the Department

Eva Filová

Department of Neuroregeneration

Research Department

Head of the Department

Pavla Jendelová

Department of Neurogenetics

Research Department

Head of the Department

Lenka Šlachtová

Department of Molecular Biology of Cancer

Research Department

Head of the Department

Veronika Vymetálková

Department of Cell Nucleus Plasticity

Research Department

Head of the Department

Helena Fulková

Department of Functional Organisation of Biomembranes

Research Department

Head of the Department

Jan Malínský

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Latest Publications

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The role of disulfide bonds in the GluN1 subunit in the early trafficking and functional properties of GluN1/GluN2 and GluN1/GluN3 NMDA receptors

 Department of Neurochemistry AutořiNetolický J.Lee S.Baráčková P.Kolcheva M.Misiachna A.Řeháková K.Kortus S.Song J-MHemelíková K.Langore E.Doderović J.Ladislav M.Ho Suh Y.Horák M. Published on 2026 Metadata J Neurosci . 2026 Feb 24:e0409252026. doi: 10.1523/JNEUROSCI.0409-25.2026. Online ahead of print.

Mitochondrial Transfer Rescues Respiration to Support De Novo Pyrimidine Biosynthesis and Tumor Progression

 Department of Molecular Biology of Cancer AutořiDubisova M.Bohacova K.Nahacka Z.Kraus D.Novak J.Dvorakova S.Brisudova P.Danešová N.Selvi S.Hrysiuk M.Endaya B.B.Botsios P.Le D.-D.T.Novotna M.Vodenková S.Truksa J.Chalupsky K.Klima K.Prochazka J.Sedlacek R.Mengarelli F.Orlando P.Tiano L.Boukalova S.Berridge M.V.Zobalova R.Neuzil J. Published on 2026 Metadata Cancer Res . 2026 Feb 16;86(4):925-939. doi: 10.1158/0008-5472.CAN-24-0737.

Nucleolus precursor bodies in human zygote pronuclei—still in the haze?

 Department of Cell Nucleus Plasticity AutořiFulka H.Loi P.Fulka J. Published on 2026 Metadata Reproduction, Volume 171, Issue 2, February 2026, Published: 23 January 2026

Impaired prepulse inhibition in APP/PS1 mice is accompanied by substantial morphological changes in neurons of the central auditory system and hippocampus

 Department of Auditory Neuroscience AutořiSvobodová Burianová J.Černotová D.Klausová T.Profant O.Fuksa J.Syka J.Svoboda J. Published on 2026 Metadata Hear Res . 2026 Jan:469:109484. doi: 10.1016/j.heares.2025.109484. Epub 2025 Nov 20.

Sensory neurons drive pancreatic cancer progression through glutamatergic neuron-cancer pseudo-synapses

 Department of Neuroregeneration AutořiRen L.Liu C.Çifcibaşı K.Ballmann M.Rammes G.Mota Reyes C.Tokalov S.Klingl A.Grünert J.Goyal K....Romanyuk N.Giesert F.Saur D.Rad R.Schmid R. M.Algül H.Krüger A.Friess H.Ceyhan G. O.Istvanffy R.Demir İ. E. Published on 2025 Metadata Cancer Cell . 2025 Dec 8;43(12):2241-2258.e8. doi: 10.1016/j.ccell.2025.09.003. Epub 2025 Sep 25.

From real-driving emissions to urban air quality: composition of aged PM from modern diesel, gasoline, and CNG fueled cars and plug-in hybrid electric vehicles

 Department of Toxicology and Molecular Epidemiology AutořiSimon L.Barreira L.Kylämäki K.Saarikoski S.Aurela M.Li D.Järvinen A.Kuutti H.Honkisz W.Jäppi M.Salo L.Rissanen M.Červená T.Vojtíšek M.Topinka J.Bielaczyc P.Rönkkö T.Aakko-Saksa P.Timonen H. Published on 2025 Metadata Atmospheric Environment: X Volume 28, December 2025, 100375 https://doi.org/10.1016/j.aeaoa.2025.100375

Association of Tinnitus With Speech Recognition and Executive Functions in Older Adults

 Department of Auditory Neuroscience AutořiSommerhalder N.Bureš Z.Profant O.Kleinjung T.Neff P.Meyer M. Published on 2025 Metadata Trends Hear . 2025 Jan-Dec:29:23312165251389585. doi: 10.1177/23312165251389585. Epub 2025 Nov 13.

Oocyte Age-Dependent DNA Damage Can Be Reverted by the DNA Repair Competent Karyoplasm of Young Oocytes

 Department of Cell Nucleus Plasticity AutořiDudko N.Ilčíková T.Novotna N.Czernik M.Loi P.Fulka J. Jr.Bhattacharjee P.Santoro R.Fulka H. Published on 2026 Metadata Aging Cell . 2025 Nov 15:e70300. doi: 10.1111/acel.70300. Online ahead of print.

Novel approaches for the discovery of pharmacogenetic biomarkers of chemotoxicity in patients with colorectal cancer

 Department of Molecular Biology of Cancer AutořiSimoes A. R.Carlés González S.Lopez-Doldan M. C.Duran G.Fernández-Montes A.Fernandez M. P.Salgado Fernandez M.Garcia Mata J.Paez D.Riera P.Guino E.Lopez-Fernandez L.Garcia de Santiago B.López Aspiroz E.Rojas A.Castells A.Castellvi-Bel S.Ruiz Ponte C.Vymetálková V.Carracedo A.Fernandez-Rozadilla C. Published on 2025 Metadata Br J Pharmacol . 2025 Nov;182(21):5340-5354. doi: 10.1111/bph.70051. Epub 2025 Jul 7.
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