Developmental Biology

The department deals with research into the genetic regulation of embryonic development. In our studies, we use tissue-specific gene inactivation (knock‑out) technologies in mice using the Cre-loxP system. We study the functions of Wnt, Shh and FGF signaling pathways and selected transcription factors, e.g. from the Meis, Hand and Pbx families. We focus on the differentiation of neural crest cells and the associated germinal development of cartilage and bone in the craniofacial area and the middle ear. We also study the cellular mechanisms of neural tissue formation derived from neural crest cells. Analyses in mouse models are complemented by experiments in Danio rerio fish embryos. In both experimental organisms, we try to clarify the genetic nature of some human developmental defects.