Institute of Experimental Medicine CAS

Morphological and functional characteristics of nerve cells in individual auditory nuclei under normal and pathological conditions are studied in the Department. Electrophysiological and histological data are correlated with changes in the animal behavior evaluated with behavioral tests. Audiological tests and MR imaging are used to characterize age-related changes in hearing in humans.

Deputy Head:

Jiří Popelář, PhD.
Phone: +420 241 062 689

Research Scientists:

Assoc. Prof. Zbyněk Bureš, PhD.
Michaela Králíková, PhD.
Jiří Popelář, PhD.
Oliver Profant, MD, PhD.
Natalia Rybalko, PhD.
Prof. Josef Syka, MD, DSc.
Assoc. Prof. Daniel Šuta, PhD.
Rostislav Tureček, PhD.

Postdoctoral Researchers:

Bohdana Hrušková, PhD.
Jana Svobodová Burianová, PhD.
Václav Vencovský, PhD.

Research Assistant:

Ing. Milan Jilek


Jan Setnička
Štěpánka Suchánková
Lenka Tůmová

PhD. Students:

Aneta Brunová, MSc
Diana Kuchárová, MD
Ondřej Novák, MSc
Tereza Prokopová, MSc
Kateryna Pysaněnko, MSc
Veronika Svobodová, MD

Undergraduate Students:

Adolf Melichar
Filip Tomáška

Important results in 2016

1. Changes in the activity of auditory cortical inhibitory interneurons after acoustic trauma were cell type- and layer-specific

Single-unit electrophysiological recording and two-photon calcium imaging in anaesthetized mice were used to evaluate the effects of acute acoustic trauma on the response properties of neurons in the core auditory cortex. The results demonstrate cell type- and layer-specific changes. The observed changes could play a role in pathogenesis of tinnitus.


An overview of in vivo calcium imaging used for studying effects of acute acoustic trauma in the mouse auditory cortex, with special focus on somatostatin- and parvalbumin-positive (SST+ and PV+) inhibitory interneurons in different cortical layers.
Calcium imaging in the auditory cortex in vivo. A) A scheme of free-field acoustic stimulation under the two-photon microscope. B) Example field of view of layer 2/3 in the auditory cortex. PV+ cells were labeled with tdTomato (red). C) Similar to B, but with labeled SST+ interneurons. All cells in B and C were also loaded with calcium indicator OGB-1 (green). D) Calcium data analysis and spiking activity inference. E) Comparison of coding properties of individual neurons before and after the acoustic trauma.

Publication: Novak O, Zelenka O, Hromadka T, and Syka J. Immediate manifestation of acoustic trauma in the auditory cortex is layer-specific and cell type-dependent. J Neurophysiol jn.00810.02015, 2016. DOI: 10.1152/jn.00810.2015

2. Processing of aversive 22-kHz rat‘s call differ in individual brain structures

The responses to aversive 22-kHz vocalization was evaluated by c-Fos mmunolabelling in different brain structures. The natural 22-kHz vocalizations was either played from a recording or produced by a foot-shocked animal located nearby (live vocalizations) or the artificial call-like stimuli was used. The natural 22-kHz vocalizations evoked larger response in auditory and limbic structures, whereas artificial call-like stimuli was less efficient in limbic structures.


Numerical density of c-Fos immunoreactive nuclei in particular brain regions in control non-stimulated rats, animals exposed to playback of 22-kHz vocalizations, animals exposed to artificial stimuli, and animals exposed to natural 22-kHz vocalizations emitted by a nearby rat.

Ouda L, Jilek M, Syka J. Expression of c-Fos in rat auditory and limbic systems following 22-kHz calls. Behav Brain Res. 2016 Jul 15;308:196-204.

 Important results in 2015

1. Age-related changes in hearing

Based on the MRI recordings from auditory cortex, it seems that peripheral as well as central components of presbycusis appear to influence each other only to a limited degree. The greater extent of cortical activation in elderly subjects in comparison with young subjects, with an asymmetry towards the right side, may serve as a compensatory mechanism for the impaired processing of auditory information appearing as a consequence of ageing.

MR Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague
Department of Otorhinolaryngology and Head and Neck Surgery, 1st Faculty of Medicine, Charles University in Prague, University Hospital Motol, Prague



Averaged cortical activity evoked by acoustic stimulation examined by fMRI in all 3 groups. YC – young controls, MP – mild presbycusis, EP – expressed presbycusis. Red colour – stimulation with pink noise centered at 350 Hz and 700 Hz; blue colour – stimulation with pink noise centered at 1.5 kHz, 3 kHz and 8 kHz. The arrowheads accentuate an increase in the right AC activation in both elderly groups.

Publication: Profant O., Tintěra J., Balogová Z., Ibrahim I., Jilek M., Syka J. (2015) Functional changes in the human auditory cortex in ageing. PLoS One. 2015 Mar 3;10(3):e0116692.

2. Deterioration of the Medial Olivocochlear Efferent System Accelerates Age-Related Hearing Loss in Pax2-Isl1 Transgenic Mice

Overexpression of transcription factor ISLET1 under the Pax2 promoter in mice manifested in hyperactivity, circling behavior, and early onset of progressive age-related hearing loss. Early age related reduction of otoacoustic emissions (DPOAEs) was found to be conditioned by deterioration of cochlear efferent terminals. Our data provide the first evidence that the alternation of MOC efferent system accelerates the age-related functional decline of hearing without the loss of OHCs.

Collaboration: Gabriela Pavlínková Ph.D., Laboratory of Molecular Pathogenetics, Institute of Biotechnology CAS, Prague
Prof. Bernd Fritzsch, Department of Biology, University of Iowa, Iowa City, IA, USA



Altered efferent innervations. Despite visible similarities, the quantitative analysis shows a decrease in the volume of MOC terminals of OHCs (A, C, arrows; quantified in M) and efferent vesiculated fibers in the region of Deiters’ cells (B, D, arrows; quantified in N) in young Tg+/− mice (I, M) than in WT animals (G, M). The progressive loss of efferent fibers is visible in older Tg+/− (J) compared toWT (H). In both WT and Tg+/− groups, efferent endings are missing if the OHC is lost (G, I; stars). Side view (E, F, K, L) represents the maximum projection of a focal series through the thickness of one OHC, arrows here and in B, D, H, J point out ChAT positive particles in the region of Deiters’ cells. MOC medial olivocochlear eferent system, IHC inner hair cells, OHC outer hair cells, DC Deiters’ cells, ChAT cholin acetyltransferaza.

Publication: Chumak T., Bohuslavova R., Macova I., Dodd N., Buckiova D., Fritzsch B., Syka J., Pavlinkova G. (2015) Deterioration of the Medial Olivocochlear Efferent System Accelerates Age-Related Hearing Loss in Pax2-Isl1 Transgenic Mice. Mol Neurobiol, [Epub ahead of print] DOI 10.1007/s12035-015-9215-1

3. Differential modulation of GABAB receptor-induced K+ currents by endogenous KCTD proteins

GABAB receptors are the G-protein coupled receptors for the main inhibitory neurotransmitter in the brain, γ-aminobutyric acid (GABA). GABAB receptors regulate the excitability of most neurons in the central nervous system by modulating the activity of enzymes and ion channels. GABAB receptors associate with homo-oligomers of auxiliary KCTD 8, 12, 12b and 16 subunits that differentially regulate the receptor response by directly binding to the G-protein. We have shown distinct regulatory effects on G-protein signaling exerted by KCTD12 and 16 and provided evidence that GABAB/KCTD16 complexes regulate the kinetics of late inhibitory postsynaptic currents in hippocampal neurons. In summary, our data demonstrate that simultaneous assembly of distinct KCTDs at the receptor increases the molecular complexity of native GABAB receptors.

Collaboration: Prof. Bernhard Bettler, Department of Biomedicine, Institute of Physiology, Pharmazentrum, University of Basel, Basel, Switzerland


A, GABAB receptor subunit compositions in neurons. The principal subunits of GABAB receptors - GABAB1 (black) and GABAB2 (white) - have the prototypical seven transmembrane domains of G protein-coupled receptors. GABAB2 associates with auxiliary KCTD12 (red) or 16 (blue) subunits. B, Altered GABAB receptor responses in neurons with deleted KCTD proteins. Representative traces of GABAB agonist baclofen-evoked K+ currents recorded from cultured hippocampal neurons of WT (black), KCTD16 (red) or KCTD12 (blue) knockout mice. Deletion of KCTD12 reduces desensitization of the responses while deletion of KCTD16 leads to slightly elevated desensitization due to higher occupancy of the receptor by KCTD12. C, Superimposed traces show K+ currents evoked by 1 s-long application of baclofen to cultured hippocampal neurons isolated from WT, KCTD12 KO or KCTD16 KO mice. Bar graph summarizes the time constants obtained from a fit of the deactivation decay to a single exponential function. Note that the decay time course of the currents was significantly reduced in KCTD16 KO and unchanged in KCTD12 KO neurons, compared to WT. D, Examples of inhibitory postsynaptic currents (IPSCs) recorded from CA1 hippocampal neurons of WT or KCTD16 KO mice. Note faster decay kinetics of the currents obtained from KCTD16 KO neurons. Bar graph summarizes the time constants obtained from a fit of the deactivation decay of IPSCs to a single exponential function.

Publication: Raveh A, Turecek R and Bettler B (2015) Mechanisms of Fast Desensitization of GABAB Receptor-Gated Currents. Adv. Pharmacol. 73C:145-165.

 Important results in 2014

 1. Age-related changes in hearing

Hearing thresholds were examined using pure-tone audiometry over the extended frequency range 0.125–16 kHz in a large sample of men and women aged 16–70 years The results could be used to normalize hearing thresholds when comparing participants differing in age and to prepare an international standard. Magnetic resonance morphometry was used to study the state of the central auditory system in a group of elderly subjects with different degree of presbycusis. The results demonstrate significant atrophy in the auditory cortex of elderly subjects.

Collaboration: The MR Unit, Department of Diagnostic and Interventional Radiology of the Institute for Clinical and Experimental Medicine (IKEM), Prague
Department of Otorhinolaryngology and Head and Neck Surgery, 1st Medical Faculty of Charles University, University Hospital Motol, Prague


Audiograms. Average pure-tone audiograms in men (top) and women (bottom) grouped by their age in decades (the parameter is age group in years). The extended high-frequency range is zoomed for clarity.

Publications: Jilek M., Šuta D., Syka J. (2014) Reference hearing thresholds in an extended frequency range as a function of age and their mathematical approximation. J Acoust Soc Am. 136(4):1821- 1830. IF1.555
Profant, O., Škoch, A., Balogová, Z., Tintěra, J., Hlinka, J., Syka, J.: (2014) Diffusion tensor imaging and MR morphometry of the central auditory pathway and auditory cortex in aging. Neuroscience 260: 87-97. IF3.327 

2. Acoustical enrichment during early postnatal development in rats improves response properties of hearing function

The study explores the effects of an acoustically enriched environment applied during the critical period of development on the responsiveness of auditory neurons in rats resulting in lower excitatory thresholds at neuronal characteristic frequency, an increased frequency selectivity, larger response magnitudes, steeper rate-intensity functions and an increased spontaneous activity. Acoustically enriched environment may permanently affect signal processing in the subcortical auditory nuclei.

Collaboration: Department of Electrical Engineering and Computer Science, College of Polytechnics, Jihlava


Enriched environment.
Neuronal excitatory thresholds and tuning bandwidth. Top – scatter diagrams showing the dependence of the excitatory threshold on the characteristic frequency (CF) of the neurons in the control and enriched groups of rats along with fifth-order polynomial regression curves. Bottom – scatter diagrams showing the dependence of the Q30 parameter on the CF of the neurons in the control and enriched groups of rats along with fifth-order polynomial regression curves.

Publication: Bureš Z., Bartošová J., Lindovský J., Chumak T., Popelář J., Syka J. (2014) Acoustical enrichment during early postnatal development changes response properties of inferior colliculus neurons in rats. Eur. J. Neurosci 2014, Vol. 40, pp. 3674–3683. IF 3.669

3. Molecular mechanism of GABAB receptor desensitization

We studied mechanisms of KCTD12-induced desensitization of GABAB receptor activated K+ currents. We show that the desensitization results from a dual interaction of KCTD12 with the G protein: constitutive binding stabilizes the heterotrimeric G protein at the receptor, whereas dynamic binding to the receptor-activated Gbg subunits induces desensitization by uncoupling Gbg from the effector K+ channel. Our results show that GABAB receptors are endowed with fast and reversible desensitization by harnessing KCTD12 that intercepts Gbg signaling.


Molecular mechanism of KCTD12-induced desensitization of GABAB responses.
A, Scheme illustrates the patch-clamp recording of membrane currents mediated by G-protein activated inwardly rectifying K+ channels (GIRK) from CHO cells. B, Representative traces of K+ currents activated by GABAB agonist baclofen in CHO cells expressing GABAB receptors and GIRK channels either with or without (w/o) KCTD12. KCTD12 induces pronounced and rapid desensitization of the K+ currents. C, Scheme illustrating a mechanism for fast desensitization of GABAB-activated GIRK currents. Resting (left), active (middle), and desensitized (right) states of the current response are shown. KCTD12 constitutively assembles with GABAB receptors and the G-protein into a signaling complex (inactive state). Constitutive binding of KCTD12 to activated Gβγ allows for a transient activation of GIRK channels (active state). An activity-dependent rearrangement of KCTD12 at Gβγ leads to a shielding of the GIRK-binding site on Gβγ by KCTD12 and induces current desensitization (desensitized state).

Publication: Tureček R, Schwenk J, Fritzius T, Ivánková K, Zolles G, Adelfinger L, Jacquier V, Besseyrias V, Gassmann M, Schulte U, Fakler B, Bettler B, (2014): Auxiliary GABAB Receptor Subunits Uncouple G Protein βγ Subunits from Effector Channels to Induce Desensitization. Neuron 82(5): 1032-1044. IF 15.982


Bureš, Z.
Software generator for spectrotemporal receptive field (STRF) measurement.

Bureš, Z., Rybalko, N.
Software system for controlling and evaluation of behavioral experiments.

Bureš, Z., Popelář, J.
Software system for evaluation of neuronal responses.

Jilek, M.
The miniature ballpoint wire electrode technology.

Jilek, M., Popelář, J.
Brain cortex cooling and temperature measuring device.


Žárská, M., Šrámek, M., Novotný, F., Havel, F., Babelová, A., Mrázková, B., Benada, O., Reinis, M., Štěpánek, I., Musilek, K., Bartek, J., Ursinyová, M., Novák, O., Dzijak, R., Kuca, K., Proská, J., Hodný, Z.: (2018) Biological safety and tissue distribution of (16-mercaptohexadecyl) trimethylammonium bromide-modified cationic gold nanorods. Biomaterials. 154: 275-290.


Bohuslavová, R., Dodd, N., Macová, I., Chumak, T., Horák, M., Syka, J., Fritzsch, B., Pavlínková, G.: (2017) Pax2-Islet1 Transgenic Mice Are Hyperactive and Have Altered Cerebellar Foliation. Molecular Neurobiology. 54(2): 1352-1368.

Bureš, Z., Popelář, J., Syka, J.: (2017) The effect of noise exposure during the developmental period on the function of the auditory system. Hearing Research. 352: 1-11.

Fík, Z., Chovanec, M., Zvěřina, E., Kluh, J., Profant, O., Kraus, J., Hrubá, S., Čada, Z., Procházková, K., Plzák, J., Betka, J.: (2017) Funkce lícního nervu po mikrochirurgické léčbě vestibulárního schwannomu. (Facial Nerve Function after Microsurgical Removal of the Vestibular Schwannoma.) Česká a Slovenská neurologie a neurochirurgie. 80 (5): 545-551.

Fritzius, T., Tureček, R., Seddik, R., Kobayashi, H., Tiao, J., Rem, P.D., Metz, M., Králíková, M., Bouvier, M., Gassmann, M., Bettler, B.: (2017) KCTD Hetero-oligomers Confer Unique Kinetic Properties on Hippocampal GABA(B) Receptor-Induced K+ Currents. Journal of Neuroscience. 37 (5): 1162-1175.

Kratochvílová, B., Profant, O., Astl, J., Holý, R.: (2017) Our experience in the treatment of idiopathic sensorineural hearing loss (ISNHL): Effect of combination therapy with HBO2 and vasodilator infusion therapy. Undersea & Hyperbaric Medicine. 43(7): 771-780.

Popelář, J. , Gómez, M.D., Lindovský, J., Rybalko, N., Burianová, J., Oohashi, T., Syka, J.: (2017) The absence of brain-specific link protein Bral2 in perineuronal nets hampers auditory temporal resolution and neural adaptation in mice. Physiological Research. 66(5): 867-880.

Profant, O. , Roth, J., Bureš, Z., Balogová, Z., Lišková, I., Betka, J., Syka, J.: (2017) Auditory dysfunction in patients with Huntington's disease. Clinical Neurophysiology. 128(10): 1946-1953.

Pysanenko, K., Bureš, Z., Lindovský, J., Syka, J.: (2017) The effect of complex acoustic environment during early development on the responses of auditory cortex neurons in rats. Neuroscience. Dec 8;371:221-228


Dvořáková, M., Jahan, I., Macová, I., Chumak, T., Bohuslavová, R., Syka, J., Fritzsch, B., Pavlinková, G.: (2016) Incomplete and delayed Sox2 deletion defines residual ear neurosensory development and maintenance. Scientific Reports. 6: 38253.

Chumak, T. , Bohuslavová, R., Macová, I., Dodd, N., Buckiová, D., Fritzsch, B., Syka, J., Pavlinková, G.: (2016) Deterioration of the Medial Olivocochlear Efferent System Accelerates Age-Related Hearing Loss in Pax2-Isl1 Transgenic Mice. Mol. Neurobiol., 53(4): 2368-2383.

Chumak, T. , Rüttiger ,L., Lee, S.C., Campanelli, D., Zuccotti, A., Singer, W., Popelář, J., Gutsche, K., Geisler, H.S., Schraven, S.P., Jaumann, M., Panford-Walsh, R., Hu, J., Schimmang, T., Zimmermann, U., Syka, J., Knipper, M.: (2016) BDNF in Lower Brain Parts Modifies Auditory Fiber Activity to Gain Fidelity but Increases the Risk for Generation of Central Noise After Injury. Mol Neurobiol. Oct;53(8):5607-27

Jírů, F., Skoch, A., Wagnerová, D., Dezortová, M., Visková, J., Profant, O., Syka, J., Hájek, M.: (2016) The age dependence of T2 relaxation times of N-acetyl aspartate, creatine and choline in the human brain at 3 and 4T. NMR Biomed., 29(3): 284-92.

Novák, O., Zelenka, O., Hromádka, T., Syka, J.: (2016) Immediate manifestation of acoustic trauma in the auditory cortex is layer specific and cell type dependent. J. Neurophysiol, 115(4): 1860-74.

Ouda L., Burianová J. , Balogová Z. , Lu H. P., Syka J.: (2016) Structural changes in the adult rat auditory system induced by brief postnatal noise exposure. Brain Struct. Funct., 221(1): 617-629.

Ouda, L., Jilek, M., Syka, J.: (2016) Expression of c-Fos in rat auditory and limbic systems following 22-kHz calls. Behav. Brain Res., 308: 196-204.

Popelář, J., Šuta, D., Lindovský, J., Bureš, Z., Pysanenko, K., Chumak, T., Syka, J.: (2016) Cooling of the auditory cortex modifies neuronal activity in the inferior colliculus in rats. Hear Res., 332: 7-16.


Burianová, J., Ouda, L., Syka, J.: (2015) The influence of aging on the number of neurons and levels of non-phosporylated neurofilament proteins in the central auditory system of rats. Front Aging Neurosci. 7: 27.

Chovanec, M., Zvěřina, E., Profant, O., Balogová, Z., Kluh, J, Syka, J., Lisý, J., Merunka, I., Skřivan, J., Betka, J.: (2015) Does attempt at hearing preservation microsurgery of vestibular schwannoma affect postoperative tinnitus? Biomed Res. Int. 2015: 783169.

Ouda, L., Profant, O., Syka, J.: (2015) Age-related changes in the central auditory system. Cell Tissue Res. 361(1): 337-358.

Profant, O. , Tintěra, J., Balogová, Z., Ibrahim, I., Jilek, M., Syka, J.: (2015) Functional changes in the human auditory cortex in ageing. PLoS One 10(3):e0116692.

Raveh, A., Tureček, R., Bettler, B.: (2015) Mechanisms of fast desensitization of GABA(B) receptor-gated currents. Adv Pharmacol. 73:145-165.

Rybalko, N., Chumak, T., Bureš, Z., Popelář, J., Šuta, D., Syka, J.: (2015) Development of the acoustic startle response in rats and its change after early acoustic trauma. Behav. Brain Res. 286: 212-221.

Školoudik, L., Chrobok, V., Kalfert, D., Koči, Z., Syková, E., Chumak, T., Popelář, J., Syka. J., Laco, J., Dědková, J., Dayanithi, G., Filip, S.:(2015) Human multipotent mesenchymal stromal cells in the treatment of postoperative temporal bone defect: an animal model. Cell Transplant., 25(7): 1405-1414.

Šuta, D., Rybalko, N. , Shen, D. W., Popelář, J., Poon, P. W., Syka J.: (2015) Frequency discrimination in rats exposed to noise as juveniles. Physiol. Behav. 144: 60-65.

Tomková, M., Tomek, J., Novák, O., Zelenka, O., Syka, J., Brom, C.: (2015) Formation and disruption of tonotopy in a large-scale model of the auditory cortex. J Comput Neurosci. 39(2):131-153.


Adelfinger, L., Tureček, R., Ivankova, K., Jensen, A. A., Moss, S. J., Gassmann, M., Bettler, B.: (2014) GABAB receptor phosphorylation regulates KCTD12-induced K+ current desensitization. Biochem. Pharmacol. 91(3): 369-379.

Betka, J., Zvěřina, E., Balogová, Z., Profant, O., Skřivan, J., Kraus, J., Lisý, J., Syka, J., Chovanec, A.: (2014) Complications of microsurgery of vestibular schwannoma. Biomed. Res. Int. 2014: 315952.

Bureš, Z., Bartošová, J., Lindovský, J., Chumak, T., Popelář, J., Syka, J.: (2014) Acoustical enrichment during early postnatal development changes response properties of inferior colliculus neurons in rats. Eur. J. Neurosci. 40(11): 3674-3683.

Jilek, M., Šuta, D., Syka, J.: (2014) Reference hearing thresholds in an extended frequency range as a function of age. J. Acoust. Soc. Am. 136(4): 1821.

Profant, O. , Škoch, A., Balogová, Z., Tintěra, J., Hlinka, J., Syka, J.: (2014) Diffusion tensor imaging and MR morphometry of the central auditory pathway and auditory cortex in aging. Neurosci. 260: 87-97.

Lu, H. P., Syka, J., Chiu, T. W., Poon, P. W.: (2014) Prolonged sound exposure has different effects on increasing neuronal size in the auditory cortex and brainstem. Hear. Res. 314: 42-50.

Trojanová, J. , Kulík, A., Janacek, J., Králíková, M., Syka, J., Tureček, R.: (2014) Distribution of glycine receptors on the surface of the mature calyx of Held nerve terminal. Front. Neural Circuits. 8: 120.

Tureček, R. , Schwenk, J., Fritzius, T., Ivankova, K., Zolles, G., Adelfinger, L., Jacquier, V., Besseyrias, V., Gassmann, M., Schult,e U., Fakler, B., Bettler, B.: (2014) Auxiliary GABAB Receptor Subunits Uncouple G Protein βγ Subunits from Effector Channels to Induce Desensitization. Neuron. 82(5): 1032-1044.


Bureš, Z. , Maršálek, P.: (2013) On the precision of neural computation with interaural level differences in the lateral superior olive. Brain Res. 1536: 16-26.

Groh, D. , Seeman, P., Jilek, M., Popelář, J., Kabelka, Z., Syka, J.: (2013) Hearing function in heterozygous carriers of a pathogenic GJB2 gene mutation. Physiol. Res. 62(3): 323-330.

Chovanec, M., Zvěřina, E., Profant, O., Skřivan, J., Cakrt, O., Lisý, J., Betka, J.: (2013) Impact of video-endoscopy on the results of retrosigmoid-transmeatal microsurgery of vestibular schwannoma: prospective study. Eur. Arch. Oto-Rhino-Laryn. 270(4): 1277-1284.

Popelář, J., Rybalko, N., Burianová, J. , Schwaller, B., Syka J.: (2013) The effect of parvalbumin deficiency on the acoustic startle response and prepulse inhibition in mice. Neurosci. Lett. 533: 216-220.

Profant, O., Balogová, Z. , Dezortová, M., Wagnerová, D., Hájek, M., Syka, J.: (2013) Metabolic changes in the auditory cortex in presbycusis demonstrated by MR spectroscopy. Exp. Gerontol. 48(8): 795-800.

Profant, O., Burianová, J., Syka, J.: (2013) The response properties of neurons in different fields of the auditory cortex in the rat. Hear. Res. 296: 51-59.

Šuta, D., Popelář, J., Burianová, J., Syka, J.: (2013) Cortical representation of species-specific vocalizations in Guinea pig. PLoS One 8(6): e65432.

Tomek, J., Novák, O., Syka, J.: (2013) Two-Photon Processor and SeNeCA - A freely available software package to process data from two-photon calcium imaging at speeds down to several ms per frame. J. Neurophysiol. 110(1): 243-256.

Wang, T., Rusu, S. I., Hrušková, B., Tureček, R., Borst, J. G.: (2013) Modulation of synaptic depression of the calyx of Held synapse by GABAB receptors and spontaneous activity. J. Physiol. (Lond.) 591(19): 4877-4894.

The role of GABAB receptors in animal models of tinnitus
GAČR, 2016-2018

Project of excellence in the field of neuroscience
GAČR 2012-2018

Processing of complex sounds in the central auditory system under normal and pathological conditions
Mezinárodní projekt GAČR, 2016-2018

Cortical changes associated with presbycusis and tinnitus – MRI study
GAČR, 2016-2018

Transcriptional regulation in neurosensory development and function in the inner ear
GAČR, 2017-2019

Functional changes of the auditory system associated with auditory experience and aging
GAČR, 2018-2020

Návrh sondy a měřícího protokolu pro otoakustické emise
TAČR, 2014-2019

Institute for Clinical and Experimental Medicine, Prague

Institute of Biotechnology Czech Academy of Science

National Chiao Tung University, Taiwan

The Czech Institute of Informatics, Robotics and Cybernetics, Czech Technical University in Prague

Motol University Hospital, Prague

Université de Bordeaux

Mail room:
building La 2. floor, room number 2.18
Mo–Fri   9:00–13:00

Data box:


Vídeňská 1083
142 20 Praha 4-Krč
Czech Republic
+420 241 062 230