Institute of Experimental Medicine CAS

The main topics studied in the Department are isolation, labelling and the use of stem cells for the treatment of brain injury, spinal cord and neurodegenerative diseases. Various types of cells (mesenchymal stem cells, neural precursor cell lines derived from fetal spinal cord, or from induced pluripotent cells) are studied, together with anti-inflammatory substances for their potential to promote the regeneration of nervous tissue. Macroporous polymeric hydrogels are used as suitable carriers for cell growth in in vitro cultures as well as for in vivo implantations facilitating the regeneration of the injured tissue. The aim of the cell therapy is to repair, replace or improve biological functions of the damaged neural tissue. For in vivo imaging of grafted cells and drug delivery we utilize magnetic nanoparticles, which are characterized in terms of cytotoxicity and genotoxicity and their influence on grafted cells and host tissue.


Deputy Head:

Lucia Urdzíková-Machová, MD, PhD.
Tel.: +420 241 062 619

Research Scientists:

Slaven Erceg, PhD.
Aleš Hejčl, MD, PhD.
Assoc. Prof. Pavla Jendelová, PhD.
Kristýna Kárová, PhD.
Petr Krůpa, MD, PhD.
Nataliya Romanyuk, PhD.
Jiří Růžička, PhD.
Karolína Turnovcová, MD, PhD.
Lucia Urdzíková-Machová, MD, PhD.
Barbora Valášková, PhD.

PhD. Students:

Ivan Arzhanov, MSc
Dana Mareková, MSc
Kateřina Neumannová, MSc
Michaela Petrovičová
Barbora Smejkalová, MSc
Ingrid Vargová, MSc

Pre-Grad Students:

Veronika Cimermanová
Lenka Gmiterková
Kristýna Šafránková
Kristýna Šintáková
Tereza Špundová
Kateřina Štěpánková


Zuzana Čermáková
Michal Douděra
Lenka Kohoutová
Karel Třešňák

Important result in 2019

The effect of hMSCs on cell death pathways in the spinal cord of ALS rats

An increasing number of studies have demonstrated the beneficial effects of human mesenchymal stem cells (hMSC) in the treatment of amyotrophic lateral sclerosis (ALS). We compared the effect of repeated intrathecal applications of hMSCor their conditioned medium (CondM) using lumbar puncture or injection into the muscle (quadriceps femoris), or a combination of both applications in symptomatic SOD1G93A rats. We further assessed the effect of the treatment on 3 major cell death pathways (necroptosis, apoptosis and autophagy) in the spinal cord tissue.

All symptomatic SOD1 rats treated with hMSC had a significantly increased lifespan, improved motor activity and reduced number of TUNEL positive cells. Moreover, a combined hMSC delivery increased motor neuron survival, maintained neuromuscular junctions in quadriceps femoris and substantially reduced the levels of proteins involved in necroptosis (Rip1, MLKL,cl-casp8), apoptosis (cl-casp 9) and autophagy (beclin 1). Furthermore, astrogliosis and elevated levels of Connexin 43 were decreased after combined hMSC treatment. The repeated application of CondM, or intramuscular injections alone, improved motor activity however, this improvement was not supported by changes at the molecular level. Our results provide new evidence that a combination of repeated intrathecal and intramuscular hMSC applications protects motor neurons and neuromuscular junctions, not only through a reduction of apoptosis and autophagy but also through the necroptosis pathway, which is significantly involved in cell death in rodent SOD1G93A model of ALS.

Repeated application of stem cells (hMSC) into spinal cord and muscles increased lifespan of the ALS rats, reduced expression of apoptotic protein cleaved caspase 9, necroptotic protein MLKL and beclin involved in autophagy (C). As a result we observed rescued motoneurons (D) and neuromuscular junctions (E) in cell treated ALS rats.


Important result in 2018

Transplantation of neural precursors generated from spinal progenitor cells reduces inflammation in spinal cord injury via NF-κB pathway inhibition

Transcription factors from the NFkB family are involved in a number of processes throughout cellular life. Mainly, they include immune responses including inflammation, cell survival, growth and development.

In our projects, we focused on determining levels of NFκB activation after experimental compression spinal cord trauma and changes in its activation after in situ transplantation of neural precursors (SPC-01) as well as on identifying mechanisms behind functional improvements induced by SPC-01 cells.

We found that activation of the NFκB pathway in the first month after injury has a bimodal character with the highest levels of activity at days 3 and 28, which reflected the host cellular response at the injury site and also correlated with infiltration waves of peripheral immune cells, which were determined by other research groups. Previously, a subacute administration of cells at 1 week after injury has been shown to be the most beneficial in transplantation therapies. In our work we showed that one of the reasons for this may be the observed decrease in NFκB activity at 7 days after the induction of injury. Administration of stem cells inhibited the pro-inflammatory NF-κB pathway with reduced TNF-α levels, and thus ameliorated the development of spinal cord injury.


Stem cells inhibit activation of inflammatory pathway in spinal cord injury

Immunohistochemical staining with hematoxylin and DAB (NF-kB p65) of spinal cord from uninjured rats (A, A1, A2), or 28 days after injury from rats treated with saline (B, B1, B2) or 28 days from rats transplanted with SPC-01 (C, C1, C2). Black arrows point to nuclei void of NF-kB p65 expression, red arrows highlight nuclei with translocated p65 and green arrows indicate cells with nuclei negative to p65 surrounded by p65+ cytoplasm (A1, A2, B1, B2, C1, C2). In the lesion center of spinal cords, a significantly lower NF-κB p65 activity was observed at 28 days in the group treated with SPC-01 cells (D). Transplantation of SPC-01 cells resulted in marked reduction of TNF-α levels 10 and 14 days after injury when compared with animals injected with saline only (E). Rats transplanted with SPC-01 cells displayed a significantly smaller cavity size than rats treated with saline (F). Reduction in gliosis was observed in the central parts of spinal cord lesion in rats transplanted with SPC-01 (G).

Important results in 2017

1. Grafted mesenchymal stem cells labeled with iron oxide or cobalt-zinc-iron nanoparticles and oxidative stress in vivo

To assess the efficacy of stem cell therapy, magnetic resonance imaging (MRI) combined with a contrast label appears to be an effective noninvasive technique for the tracking of transplanted stem cells in living organisms. The application of MRI in vivo requires the use of a safe contrast agent, that is, the achievement of a sufficient level of cell labeling for MRI and, simultaneously, biocompatibility of the label with stem cells and the host tissue without any side effects on their biological properties and functions.

Rat mesenchymal stem cells (rMSCs) labeled with 1) poly-l-lysine-coated superparamagnetic iron oxide nanoparticles or 2) silica-coated cobalt-zinc-iron nanoparticles were implanted into the left brain hemisphere of rats, to assess their effects on the levels of oxidative damage to biological macromolecules in brain tissue. Animals were sacrificed 24 hours or 4 weeks after the treatment, and the implantation site along with the surrounding tissue was isolated from the brain. The comet assay with enzymes of excision DNA repair (endonuclease III and formamidopyrimidine-DNA glycosylase) was used to analyze breaks and oxidative damage to DNA in the brain tissue. Oxidative damage to proteins and lipids was determined by measuring the levels of carbonyl groups and 15-F 2t -isoprostane (enzyme-linked immunosorbent assay). In histological sections, the expression of glial fibrillary acidic protein and CD68 was analyzed to detect astrogliosis and inflammatory response.

MRI displayed implants of labeled cells as extensive hypointense areas in the brain tissue. The signal was clearly visible within 4 weeks after implantation of rMSCs. No increase of oxidative damage to DNA, lipids, or proteins over the control values was detected in any sample of brain tissue from the treated animals. Also, immunohistochemistry did not indicate any serious tissue impairment around the graft.


The transplantation of magnetically labeled cells into the rat brain did not show any damage to the macromolecules of the nerve tissue (A-C) or induced any inflammatory reaction (D-F). Magnetically labeled cells, unlike unlabeled (G), were well visible at MRI. (H, I).

Publication: Novotna B, Herynek V, Rossner P Jr, Turnovcova K, Jendelova P.: The effects of grafted mesenchymal stem cells labeled with iron oxide or cobalt-zinc-iron nanoparticles on the biological macromolecules of rat brain tissue extracts. Int J Nanomedicine. 2017 Jun 20;12:4519-4526

2. A green tea polyphenol epigallocatechin-3-gallate enhances neuroregeneration after spinal cord injury by altering levels of inflammatory cytokines

Spinal cord injury (SCI) is a debilitating condition which is characterized by an extended secondary injury due to the presence of inflammatory local milieu. Epigallocatechin gallate (EGCG) appears to possess strong neuroprotective properties. Here, we evaluated the beneficial effect of EGCG on recovery from SCI. Male Wistar rats were given either EGCG or saline directly to the injured spinal cord and thereafter a daily IP injection. The results demonstrated that EGCG-treated rats displayed a superior behavioral performance in a flat beam test, higher axonal sprouting and positive remodelation of glial scar. Cytokine analysis revealed a reduction in IL-6, IL2, MIP1α and RANTES levels on days 1 and 3, and an upregulation of IL-4, IL-12p70 and TNFα 1 day following SCI in EGCG-treated rats. Treatment with EGCG was effective in decreasing the nuclear translocation of subunit p65 (RelA) of the NF-κB dimer, and therefore canonical NF-κB pathway attenuation. A significant increase in the gene expression of growth factors (FGF2 and VEGF), was noted in the spinal cord of EGCG-treated rats.


The image A shows transveral section of the spinal cord lesion stained with hematoxyline and NF-κB - DAB staining after EGCG treatment. The nuclear translocation of subunit p65 (RelA) of the NF-κB dimer (black arrows), nuclei stained with hematoxylin without NF-κB (red arrow) and cells with NF-κB in cell cytoplasm (green arrows). Bar A = 500 μm, Bar A1 = 20 μm. EGCG treatment significantly supports axonal sprouting in spinal cord lesion (B). Locomotor improvement (flat beam test) was observed in animals treated with EGCG when compared with control (C). Levels of proinflammatory cytokines 1 and 3 days after SCI in EGCG and saline-treated groups (D).


Androvic, P., Romanyuk, N., Urdziková-Machová, L., Rohlová, E,., Kubista, M., Valihrach, L.: (2019) Two-tailed RT-qPCR panel for quality control of circulating microRNA studies.  Scientific Reports. 9: 4255.

Artero Castro, A., Machuca, C., Rodriguez Jimenez, F.J., Jendelová, P., Erceg, S.: (2019) Short Review: Investigating ARSACS: models for understanding cerebellar degeneration. Neuropathology and Applied Neurobiology.45(6): 531-537.

Artero Castro, A., Rodríguez Jimenez, F.J., Jendelová, P., Erceg, S.: (2019) Deciphering Retinal Diseases through the Generation of Three Dimensional Stem Cell-derived Organoids. Stem Cells.

Artero-Castro, A., Popelka, Š., Jendelová, P., Motlík, J., Ardan, T., Jimenez, F.J.R., Erceg, S.: (2019)  The identification of small molecules that stimulate retinal pigment epithelial cells: potential novel therapeutic options for treating retinopathies. Expert Opinion on Drug Discovery. 14 (2): 169-177.

Herynek, V., Turnovcová, K., Galisová, A., Kaman, O., Mareková, D., Koktan, J., Vosmanská, M., Kosinoá, L., Jendelová, P.: (2019) Manganese-Zinc Ferrites: Safe and Efficient Nanolabels for Cell Imaging and Tracking In Vivo. ChemistryOpen. 8(2): 155-165.

Horák, D., Plichta, Z., Mareková, D., Turnovcová, K., Kaiser, R., Jendelová, P.: (2019) Poly[N‐(2‐hydroxypropyl)methacrylamide]‐modified magnetic γ‐F2O3 nanoparticles conjugated with doxorubicin for glioblastoma treatment. ChemMedChem.

Chudíčková, M., Vacková, I., Machová Urdzíková L., Jancová, P., Kekulová, K., Řehořová, M., Turnovcová, K., Jendelová, P., Kubinová, S. : (2019) The Effect of Wharton Jelly-Derived Mesenchymal Stromal Cells and Their Conditioned Media in the Treatment of a Rat Spinal Cord Injury. International Journal of Molecular Sciences. 20: 4516.

Jirák, D., Ziolkowska, N., Turnovcová, K., Kárová, K., Syková, E., Jendelová, P., Romanyuk, N.: (2019) Metabolic Changes in Focal Brain Ischemia in Rats Treated With Human Induced Pluripotent Stem Cell-Derived Neural Precursors Confirm the Beneficial Effect of Transplanted Cells. Frontiers in Neurology.10:1074.

Jiráková, K., Moskvin, M., Machová Urdzíková, L., Rössner, P., Elzeinová, F., Chudíčková, M., Jirák, D., Ziolkowská, N., Horák, D., Kubinová, Š., Jendelová, P.: (2019) The negative effect of magnetic nanoparticles with ascorbic acid on peritoneal macrophages. Neurochemical Research.

Krůpa, P., Svobodová, B., Dubišová, J., Kubinová, Š., Jendelová, P., Machová Urdzíková, L. : (2019) Nano-formulated curcumin (Lipodisq (TM)) modulates the local inflammatory response, reduces glial scar and preserves the white matter after spinal cord injury in rats. Neuropharmacology. 155: 54-64.

Machuca, C., Vilches, A., Clemente, E., Pascual-Pascual, S.I., Bolinches-Amoros, A., Castro, A.A., Espinos, C., Leon, M., Jendelová, P., Erceg, S.: (2018) Generation of human induced pluripotent stem cell (iPSC) line from an unaffected female carrier of mutation in SACSIN gene. Stem Cell Research. 33: 166-170.

Neumannová, K., Machová-Urdzíková, L., Kwok, J.C.F., Fawcett, J.W., Jendelová, P. : (2019) Adaptation of tape removal test for measurement of sensitivity in perineal area of rat. Experimental Neurology.

Opattová A., Horák, J., Vodenková, S., Kostovciková K., Čumová, A., Macinga,P., Galanová, N., Rejhová, A., Vodičková, L., Kozics, K., Turnovcová, K., Hucl, T., Slíva, D., Vodička, P.: (2019) Ganoderma Lucidum induces oxidative DNA damage and enhances the effect of 5-Fluorouracil in colorectal cancer in vitro and in vivo. Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 845: 403065.

Petrenko, Y., Chudičková, M., Vacková, I., Groh, T., Košnarová, E., Čejková, J., Turnovcová, K., Petrenko, A., Syková, E., Kubinová, Š.: (2019) Clinically Relevant Solution for the Hypothermic Storage and Transportation of Human Multipotent Mesenchymal Stromal Cells. Stem Cells International. 2019: 590952.

Růžička, J., Romanyuk, N., Jiráková, K., Hejčl, A., Janoušková, O., Machová Urdziková, L., Bochin, M., Přádný, M., Vargová, L., Jendelová, P.: (2019) The Effect of iPS-Derived Neural Progenitors Seeded on Laminin-Coated pHEMA-MOETACl Hydrogel with Dual Porosity in a Rat Model of Chronic Spinal Cord Injury. Cell Transplantation. 28 (4): 400-412.

Růžička, J., Urdziková Machová, L., Kloudová, A., Amin, A.G., Vallová, J., Kubinová, Š., Schmidt, M.H., Jhanwar-Uniyal, M., Jendelová, P.: (2018) Anti-inflammatory compound curcumin and mesenchymal stem cells in the treatment of spinal cord injury in rats. Acta Neurobiologiae Experimentalis. 78(4): 358-374.

Řehořová, M., Vargová, I., Forostyak, S., Vacková, I., Turnovcová, K., Kupcová Skalníková, H., Vodička, P., Kubinová, S., Syková, E., Jendelová, P.: (2019) A Combination of Intrathecal and Intramuscular Application of Human Mesenchymal Stem Cells Partly Reduces the Activation of Necroptosis in the Spinal Cord of SOD1(G93A) Rats. Stem Cells Translational Medicine. 8 (6): 535-547.

Svobodová, B., Kloudová, A., Růžička, J., Kajtmanová, L., Navrátil, L., Sedláček, R., Suchý, T., Jhanwar-Uniyal, M., Jendelová, P., Machová Urdziková, L.: (2019) The effect of 808 nm and 905 nm wavelength light on recovery after spinal cord injury. Scientific Reports. 9: 7660.

Výborný, K., Vallová, J., Kočí, Z., Kekulová, Jiráková, K., Jendelová, P., Hodan, J., Kubinová, Š.: (2019) Genipin and EDC crosslinking of extracellular matrix hydrogel derived from human umbilical cord for neural tissue repair.  Scientific Reports. 9: 10674.

Skalnikova HK, Bohuslavova B, Turnovcova K, Juhasova J, Juhas S, Rodinova M, Vodicka P. Isolation and Characterization of Small Extracellular Vesicles from Porcine Blood Plasma, Cerebrospinal Fluid, and Seminal Plasma. Proteomes. 2019 Apr 25;7(2). pii: E17. doi: 10.3390/proteomes7020017. PubMed PMID: 31027284; PubMed Central PMCID: PMC6630935.

Petrenko Y, Chudickova M, Vackova I, Groh T, Kosnarova E, Cejkova J, Turnovcova K, Petrenko A, Sykova E, Kubinova S. Clinically Relevant Solution for the Hypothermic Storage and Transportation of Human Multipotent Mesenchymal
Stromal Cells. Stem Cells Int. 2019 Jan 20;2019:5909524. doi: 10.1155/2019/5909524. eCollection 2019. PubMed PMID: 30805009; PubMed Central PMCID: PMC6360551.



Ruzicka J, Urdzikova LM, Kloudova A, Amin AG, Vallova J, Kubinova S, Schmidt MH, Jhanwar-Uniyal M, Jendelova P. Anti-inflammatory compound curcumin and mesenchymal stem cells in the treatment of spinal cord injury in rats. Acta Neurobiol Exp (Wars). 2018;78(4):358-374.

Artero-Castro A, Popelka S, Jendelova P, Motlik J, Ardan T, Rodriguez Jimenez FJ, Erceg S. The identification of small molecules that stimulate retinal pigment epithelial cells: potential novel therapeutic options for treating retinopathies. Expert Opin Drug Discov. 2019 Jan 8:1-9. doi: 10.1080/17460441.2019.1559148.

Plichta Z, Kozak Y, Panchuk R, Sokolova V, Epple M, Kobylinska L, Jendelová P, Horák D. Cytotoxicity of doxorubicin-conjugated poly[N-(2-hydroxypropyl)methacrylamide]-modified γ-Fe(2)O(3) nanoparticles towards human tumor cells. Beilstein J Nanotechnol. 2018 Sep 25;9:2533-2545. doi: 10.3762/bjnano.9.236.

Jendelova P, Sykova E, Erceg S. Neural Stem Cells Derived from Human-Induced Pluripotent Stem Cells and Their Use in Models of CNS Injury. Results Probl Cell Differ. 2018;66:89-102. doi: 10.1007/978-3-319-93485-3_3.

Hejčl A, Růžička J, Kekulová K, Svobodová B, Proks V, Macková H, Jiránková K, Kárová K, Machová Urdziková L, Kubinová Š, Cihlář J, Horák D, Jendelová P. Modified Methacrylate Hydrogels Improve Tissue Repair after Spinal Cord Injury. Int J Mol Sci. 2018 Aug 22;19(9). pii: E2481. doi: 10.3390/ijms19092481.

Hejčl A, Růžička J, Proks V, Macková H, Kubinová Š, Tukmachev D, Cihlář J, Horák D, Jendelová P. Dynamics of tissue ingrowth in SIKVAV-modified highly superporous PHEMA scaffolds with oriented pores after bridging a spinal cord transection. J Mater Sci Mater Med. 2018 Jun 25;29(7):89. doi: 10.1007/s10856-018-6100-2.

Krupa P, Vackova I, Ruzicka J, Zaviskova K, Dubisova J, Koci Z, Turnovcova K, Urdzikova LM, Kubinova S, Rehak S, Jendelova P. The Effect of Human Mesenchymal Stem Cells Derived from Wharton's Jelly in Spinal Cord Injury Treatment Is Dose-Dependent and Can Be Facilitated by Repeated Application. Int J Mol Sci. 2018 May 17;19(5). pii: E1503. doi: 10.3390/ijms19051503.

Bolinches-Amorós A, Lukovic D, Castro AA, León M, Kamenarova K, Kaneva R, Jendelova P, Blanco-Kelly F, Ayuso C, Cortón M, Erceg S. Generation of a human iPSC line from a patient with congenital glaucoma caused by mutation in CYP1B1 gene. Stem Cell Res. 2018 Apr;28:96-99. doi: 10.1016/j.scr.2018.01.004.

Ruzicka J, Urdzikova LM, Svobodova B, Amin AG, Karova K, Dubisova J, Zaviskova K, Kubinova S, Schmidt M, Jhanwar-Uniyal M, Jendelova P. Does combined therapy of curcumin and epigallocatechin gallate have a synergistic neuroprotective effect against spinal cord injury? Neural Regen Res. 2018 Jan;13(1):119-127. doi: 10.4103/1673-5374.224379.

Artero Castro A, Lukovic D, Jendelova P, Erceg S. Concise Review: Human Induced Pluripotent Stem Cell Models of Retinitis Pigmentosa. Stem Cells. 2018 Apr;36(4):474-481. doi: 10.1002/stem.2783. Epub 2018 Feb 7. Review.

Karova, K., Wainwright, J.V, Machova-Urdzikova, L., Rishikaysh Pisal, R.V., Schmidt, M., Jendelova, P., Jhanwar-Uniyal, M. Transplantation of neural precursors generated from spinal progenitor cells reduces inflammation in spinal cord injury via NF-κB pathway inhibition. J Neuroinflammation in press doi: 10.1186/s12974-019-1394-7.



Forostyak, S. , Syková, E.: (2017) Neuroprotective Potential of Cell-Based Therapies in ALS:From BenchtoBedside. Frontiers in Neuroscience. 11: 591.

Hejčl, A. , Vondráková, K., Kelbich, P., Sameš, M., Tsenov, G., Kačer, P.: (2017) Model cerebrálních vazospasmů a metabolomické mapování. (A Model of Cerebral Vasospasms and Metabolomic Mapping.) Chemické listy. 111(1): 56-61.

Herynek, V., Gálisová, A., Srinivas, M., van Dinther, E.A.W., Kosinová, E., Růžička, J., Jirátová, K., Kříž, J., Jirák, D.: (2017) Pre-Microporation Improves Outcome of Pancreatic Islet Labelling for Optical and F-19 MR Imaging. Biological Procedures Online. 19: 6.

Kaman, O., Dědourková, T., Koktan, J., Kuličková, J., Maryško, M., Veverka, P., Havelek, R., Královec, K., Turnovcová, K., Jendelová, P., Schröfel, A., Svoboda, L.: (2016) Silica-coated manganite and Mn-based ferrite nanoparticles: a comparative study focused on cytotoxicity. Journal of Nanoparticle Research. 18(4): 1-18, č. článku 100.

Kočí, Z., Výborný, K., Dubišová, J., Vacková, I. , Jäger, A., Lunov, O., Jiráková, K., Kubinová, Š.: (2017) Extracellular Matrix Hydrogel Derived from Human Umbilical Cord as a Scaffold for Neural Tissue Repair and Its Comparison with Extracellular Matrix from Porcine Tissues. Tissue Engineering part C- Methods. 23(6): 333-345.

Lukovic, D., Diez Lloret, A., Stojkovic, P., Rodríguez-Martínez, D., Arago, M.P.P., Rodriguez-Jiménez, F.J., González-Rodríguez, P., López-Barneo, J., Syková, E., Jendelová, P., Kostic, J., Moreno-Manzano, V., Stojkovic, M., Bhattacharya, S.S., Erceg, S.: (2017) Highly Efficient Neural Conversion of Human Pluripotent Stem Cells in Adherent and Animal-Free Conditions. Stem Cells Translational Medicine. 6(4): 1217-1226.

Lukovic, D., Moreno-Manzano, V., Rodriguez-Jimenez, F.J., Vilches, A., Syková, E., Jendelová, P., Stojkovic, M., Erceg S.: (2017) HiPSC Disease Modeling of Rare Hereditary Cerebellar Ataxias: Opportunities and Future Challenges. Neuroscientist. 23(5): 554-566.

Machová-Urdzíková, L., Růžička, J., Kárová, K., Kloudová, A., Svobodová, B., Anubhav, A., Dubišová, J., Schmidt, M., Kubinová, Š., Jhanwar Uniyal, M., Jendelová, P.: (2017) A green tea polyphenol epigallocatechin-3-gallate enhances neuroregeneration after spinal cord injury by altering levels of inflammatory cytokines. Neuropharmacology. 126: 213-223.

Novotná, B. , Herynek, V., Rössner ml., P., Turnovcová, K., Jendelová, P.: (2017) The effects of grafted mesenchymal stem cells labeled with iron oxide or cobalt-zinc-iron nanoparticles on the biological macromolecules of rat brain tissue extracts. International Journal of Nanomedicine. 12: 4519-4526.

Růžička, J., Machová Urdziková, L., Gillick, J., Amemori, T., Romayuk, N., Kárová, K., Závišková, K., Dubišová, J., Kubinová, Š., Murali, R., Syková, E., Jhanwar-Uniyal, M., Jendelová, P.: (2017) A Comparative Study of Three Different Types of Stem Cells for Treatment of Rat Spinal Cord Injury. Cell Transplantation. 26(4): 585-603.

Syková, E. , Rychmach, P., Drahorádová, I., Konrádová, Š., Růžičková, K., Voříšek, I., Forostyak, S., Homola, A., Bojar, M.: (2017) Transplantation of Mesenchymal Stromal Cells in Patients With Amyotrophic Lateral Sclerosis: Results of Phase I/IIa Clinical Trial. Cell Transplantation. 26(4): 647-658.

Tyzack, G.E., Hall, E.C., Sibley, Ch.R., Cymes, T., Forostyak, S., Carlino, G., Meyer, I.F., Schiavo, G., Zhang, S.Ch., Gibbons, G.M., Newcombe, J., Patani, R., Lakatos, A.: (2017) A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models. Nature Communications. 8: 1164.

Center of Reconstruction Neuroscience – NEURORECON CZ.02.1.01/0.0/0.0/15_003/0000419 Coordinator Pavla Jendelova 2017–2022

Experimental transplantation of retinal pigment epithelial cells on a large animal model, GAČR 18-04393S, 2018-2020

MicroRNAs in Nervous System Injuries: Possible role and therapeutic relevance, GAČR 18-21942S, Principal Investigator Nataliya Romanyuk, PhD, 2018-2020

Study of signaling pathways associated with secondary reactions, formation of reactive oxygen radicals and inflammation in spinal cord injury and subsequent regeneration. The Ministry of Education, Youth and Sports, program InterExcelence, InterAction LTAUSA17120, Principal Investigator Jendelova 2017-2020.

Institute for Clinical and Experimental Medicine
Institute of Macromolecular Chemistry CAS
Physical Institute CAS
2nd Faculty of Medicine, Charles University
Faculty of Medicine Hradec Králové, Charles University
Faculty of Biomedical Engineering, Czech Technical University
Faculty of Mechanical Engineering, Czech Technical University
Cambridge University, UK
University of Leeds, UK
Centro de Investigación Príncipe Felipe, Valencia, Spain
New York Medical College, Valhalla, USA

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