RNDr. Antonín Ambrož, Ph.D. / Department of Nanotoxicology and Molecular Epidemiology
In everyday life, humans are exposed to toxic substances of anthropogenic origin. These substances can also be found in the ambient air and their impact poses a long-term risk for human health. PM2.5 particles is intensively studied, along with polyaromates (PAHs), bound to it, such as benzo[a]pyrene (B[a]P). PM2.5 have the ability to penetrate into the organism primarily via the airways, and represent an increased health risk compared to larger particles. PAHs affect organisms via genotoxic, mutagenic, carcinogenic, embryotoxic and other adverse effects. One of the common denominators of these effects is oxidative stress. Oxidative damage induced by ROS may affect cellular macromolecule. Since PAHs can cross the placenta, air pollution may impact a developing fetus via maternal exposure. We investigated the impact of air pollutants on biomarkers [oxidative damage to DNA (8-oxodG) and lipids (15-F2t-IsoP)] in mothers/newborns from localities differing in air pollution. Our data suggests that PM2.5 and B[a]P have an effect on oxidative damage in newborns in a more polluted region.